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Background. The number of people residing in nursing homes has increased. General practitioners (GPs) receive an increased capitation fee for elderly patients in recognition of their higher consultation rate. However, there is no distinction between elderly patients residing in nursing homes and those in the community. Aim. To determine whether nursing home residents receive greater general pra...

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Ciliopathies are a group of developmental disorders that manifest with multi-organ anomalies. Mutations in TMEM67 (MKS3) cause a range of human ciliopathies, including Meckel-Gruber and Joubert syndromes. In this study we describe multi-organ developmental abnormalities in the Tmem67 knockout mouse that closely resemble those seen in Wnt5a and Ror2 knockout mice. These include pulmonary hypopla...

Cannulating in haemodialysis: rope-ladder or buttonhole technique?

BACKGROUND The standard technique for fistula cannulation, the rope-ladder technique, is problematic for patients with short fistula lengths and for patients in whom the fistula is difficult to cannulate. The buttonhole technique, cannulation of exactly the same site, offers the advantage of an easy cannulation procedure. However, it can be used only in native fistulas and cannulation is prefer...

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Comfort, W.W. and J. van Mill, Some topological groups with, and some without, proper dense subgroups, Topology and its Applications 41 (1991) 3-15. Continuing earlier investigations into the question cf the existence of a proper dense subgroup of a given topological group, the authors obtain some positive and some negative results, as follows: (a) Every non-degenerate connected Abelian group c...